Published Work

Literary & Scientific Accomplishments

August 2019; 24 (4) | Orhto Fyto

The power of intermittent fasting - NL only (De kracht van intermittent fasting)

Over the past 10 years, intermittent fasting substantially increased in popularity, as a result of its health benefits. Fasting has a long evolutionary and historical history and is closely related to the development of different kinds of animal species, amongst which homo sapiens. Flexibility to be able to store energy during excess and release deposits during scarcity is a direct reflection of this development.

April 1, 2019 | Unieboek Spectrum

De dr. Ludid Vastenmethode - Intermittent fasting: verantwoord vasten voor iedereen - NL only

dr. Ludidi's best seller book about intermittent fasting and healthy living. Including diet plans and delicious & nutritious recipes. Dutch only.

Neurogastroenterol Motil - July 2017

Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome.

AIM

The aim of this study was to provide insight in biological processes associated with visceral hypersensitivity. Fecal and plasma biomarkers were measured in normosensitive and hypersensitive IBS patients.

CONCLUSIONS & INFERENCES

Our findings do not support a role for the biological processes as ascertained by biomarkers in visceral hypersensitivity in IBS patients. This study is registered in the US National Library of Medicine (clinicaltrials.gov, NCT00775060).

Aliment Pharmacol Ther - January 2016

Alterations in serotonin metabolism in the irritable bowel syndrome

AIM

To compare platelet poor plasma (PPP) 5-HT and 5-hydroxyindole acetic acid (5-HIAA) levels and their ratio in a large cohort of IBS patients and healthy controls (HC), including IBS-subgroup analysis.

CONCLUSIONS

We demonstrated that fasting 5-HT plasma levels are not significantly different in IBS patients compared to controls. However, decreased 5-HIAA levels and 5-HIAA/5-HT ratio in IBS patients may reflect altered serotonin metabolism in IBS. Gender affects 5-HIAA levels in IBS patients, but no effects of drugs, such as SSRIs, or higher GI-symptom or psychological scores were found.

PLoS One - May 2015

The intestinal barrier in irritable bowel syndrome: subtype-specific effects of the systemic compartment in an in vitro model

AIM

We aimed to assess effects of tryptase and LPS on in vitro permeability using a 3-dimensional cell model after basolateral cell exposure. Furthermore, we assessed the extent to which these mediators in IBS plasma play a role in intestinal barrier function.

CONCLUSION

Basolateral exposure of spheroids to plasma of IBS-D patients resulted in a significantly increased FD4 permeation, which was partially abolished by selective inhibition of tryptase and LPS. These findings point to a role of systemic tryptase and LPS in the epithelial barrier alterations observed in patients with IBS-D.

Aliment Pharmacol Ther - August 2014

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders

AIMS

To assess intestinal permeability at different sites of the GI tract in different subtypes of well-characterised IBS patients and healthy controls (HC), and to assess potential confounding factors.

CONCLUSIONS

Small intestinal permeability is increased in patients with IBS-D compared to healthy controls, irrespective of confounding factors. Adjustment for confounders is necessary when studying intestinal permeability, especially in a heterogeneous disorder such as IBS.

Neurogastroenterol Motil - Aug 2014

Markers for visceral hypersensitivity in patients with irritable bowel syndrome

AIM

Aim of our study was to compare in detail a large group of hyper- vs normosensitive IBS patients with respect to epidemiological and clinical characteristics.

CONCLUSIONS & INFERENCES

Apart from more severe symptomatology, hypersensitive IBS patients are characterized by significantly younger age compared with normosensitive IBS patients. The study has been registered in the US National Library of Medicine.

Neurogastroenterol Motil - May 2014

Randomized clinical trial on the effect of a multispecies probiotic on visceroperception in hypersensitive IBS patients

AIM

We performed a study in IBS patients, characterized by visceral hypersensitivity measured with the rectal barostat, aiming to assess the effect of 6 weeks of multispecies probiotic mix on visceral pain perception.

CONCLUSIONS & INFERENCES

In this placebo-controlled trial in IBS patients with visceral hypersensitivity, no significant effect of a multispecies probiotic on viscerperception was observed. The study has been registered in the US National Library of Medicine (http://www.clinicaltrials.gov, NCT00702026).

Eur J Pain - October 2013

Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: a role in pain symptom generation?

AIM

We hypothesized that increased pain perception in IBS could be explained by increased transcription in TRPV1 and/or altered levels of neuropeptides. We therefore assessed the transcription of TRPV1 and the mucosal concentration of somatostatin and SP in IBS in comparison to healthy volunteers and patients with ulcerative colitis (UC) in remission as disease controls, and to ascertain their relationship to pain symptoms.

CONCLUSION

Increased transcription of TRPV1 may provide a possible explanation for pain generation in IBS. While the neuropeptides SP and somatostatin were both found to be increased in IBS, these changes are not sufficient to explain pain generation. Pain generation in IBS is probably explained by a complex redundancy in the regulation of local nociceptive mechanisms, which remains a subject of intensive investigation.


Comment in

Colorectal Dis  - January 2013

Effect of cholecystokinin on rectal motor and sensory function in patients with irritable bowel syndrome and healthy controls

AIM

Ingestion of a meal frequently induces an urge to defaecate, the so-called gastro-colonic or gastro-rectal reflex. In patients with irritable bowel syndrome (IBS), symptoms are often provoked by meals. Cholecystokinin (CCK), a proximal gut peptide released after ingestion of a meal, may mediate these postprandial changes. The potential role of CCK in rectal sensory and motor function was evaluated by a rectal barostat study in healthy controls and patients with IBS.

CONCLUSION

Infusion of exogenous CCK to plasma levels normally seen in the postprandial state did not influence rectal motor function or sensations during ramp distension but it did significantly increase pain sensation in IBS patients during rapid intermittent distension.

Neurogastorenterol Motil - August 2012

Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff

AIM

We aimed to calculate the optimal cutoff to detect visceral hypersensitivity in IBS.

CONCLUSIONS & INFERENCES

Optimal cutoff for visceral hypersensitivity was found at pressure 26 mmHg with a VAS ≥20 mm, resulting in 63.5% of IBS patients being hypersensitive and 11% being allodynic. Standardization of barostat procedures and defining optimal cutoff values for hypersensitivity is warranted when employing rectal barostat measurements for research or clinical purposes.

Eur J Pain  - November 2012

Revisiting concepts of visceral nociception in irritable bowel syndrome

BACKGROUND AND OBJECTIVE

Irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain related to defecation with a change in bowel habit. Patients with IBS often exhibit increased visceral sensitivity, which can be tested clinically by rectal balloon distension procedures. This paper aims to give an overview of mechanisms involved in visceral hypersensitivity in IBS by reviewing recent literature.

CONCLUSION

Alterations in the modulatory balance of pro- and antinociceptive central processing of noxious peripheral input may serve as in integrative hypothesis for explaining visceral hypersensitivity in IBS. Nevertheless, it remains troublesome to estimate the contribution of central and peripheral factors in visceral hypersensitivity, posing a challenge in determining effective therapeutic entities.

Neurogastroenterol Motil - january 2012

Does meal ingestion enhance sensitivity of visceroperception assessment in irritable bowel syndrome?

AIM

We investigated whether meal ingestion could increase the sensitivity of the barostat procedure for the detection of visceral hypersensitivity in IBS patients.

CONCLUSIONS & INFERENCES

Postprandial barostat measurement enhances visceroperception in IBS but has no added value to detect visceral hypersensitivity in individual IBS patients.

 

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