Literary & Scientific Accomplishments

October 2020 - Ubunda Publishers

The Dr. Ludidi Method of Intermittent Fasting

Ludidi's best seller book about intermittent fasting and healthy living. Including diet plans and delicious & nutritious recipes. English edition.

August 2019 - Ortho Fyto 

The power of Intermittent Fasting [NL]

Over the past 10 years, intermittent fasting substantially increased in popularity. Fasting has a long evolutionary and historical history and is closely related to the development of different kinds of animal species, amongst which homo sapiens. Flexibility to be able to store energy during excess and release deposits during scarcity is a direct reflection of this development.

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April 2019 - Unieboek Spectrum

De dr. Ludid Vastenmethode - Intermittent fasting: verantwoord vasten voor iedereen [NL]

dr. Ludidi's best seller book about intermittent fasting and healthy living. Including diet plans and delicious & nutritious recipes. Dutch edition.

July 2017 - Neurogastroenterol Motil

Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome.


The aim of this study was to provide insight in biological processes associated with visceral hypersensitivity. Fecal and plasma biomarkers were measured in normosensitive and hypersensitive IBS patients.


Our findings do not support a role for the biological processes as ascertained by biomarkers in visceral hypersensitivity in IBS patients. This study is registered in the US National Library of Medicine (, NCT00775060).

January 2016 - Aliment Pharmacol Ther

Alterations in serotonin metabolism in the irritable bowel syndrome


To compare platelet poor plasma (PPP) 5-HT and 5-hydroxyindole acetic acid (5-HIAA) levels and their ratio in a large cohort of IBS patients and healthy controls (HC), including IBS-subgroup analysis.


We demonstrated that fasting 5-HT plasma levels are not significantly different in IBS patients compared to controls. However, decreased 5-HIAA levels and 5-HIAA/5-HT ratio in IBS patients may reflect altered serotonin metabolism in IBS. Gender affects 5-HIAA levels in IBS patients, but no effects of drugs, such as SSRIs, or higher GI-symptom or psychological scores were found.

May 2015 - PLoS One

The intestinal barrier in irritable bowel syndrome: subtype-specific effects of the systemic compartment in an in vitro model


We aimed to assess effects of tryptase and LPS on in vitro permeability using a 3-dimensional cell model after basolateral cell exposure. Furthermore, we assessed the extent to which these mediators in IBS plasma play a role in intestinal barrier function.


Basolateral exposure of spheroids to plasma of IBS-D patients resulted in a significantly increased FD4 permeation, which was partially abolished by selective inhibition of tryptase and LPS. These findings point to a role of systemic tryptase and LPS in the epithelial barrier alterations observed in patients with IBS-D.

August 2014 - Aliment Pharmacol Ther

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders


To assess intestinal permeability at different sites of the GI tract in different subtypes of well-characterised IBS patients and healthy controls (HC), and to assess potential confounding factors.


Small intestinal permeability is increased in patients with IBS-D compared to healthy controls, irrespective of confounding factors. Adjustment for confounders is necessary when studying intestinal permeability, especially in a heterogeneous disorder such as IBS.

August 2014 - Neurogastroenterol Motil

Markers for visceral hypersensitivity in patients with irritable bowel syndrome


Aim of our study was to compare in detail a large group of hyper- vs normosensitive IBS patients with respect to epidemiological and clinical characteristics.


Apart from more severe symptomatology, hypersensitive IBS patients are characterized by significantly younger age compared with normosensitive IBS patients. The study has been registered in the US National Library of Medicine.

May 2014 - Neurogastroenterol Motil

Randomized clinical trial on the effect of a multispecies probiotic on visceroperception in hypersensitive IBS patients


We performed a study in IBS patients, characterized by visceral hypersensitivity measured with the rectal barostat, aiming to assess the effect of 6 weeks of multispecies probiotic mix on visceral pain perception.


In this placebo-controlled trial in IBS patients with visceral hypersensitivity, no significant effect of a multispecies probiotic on viscerperception was observed. The study has been registered in the US National Library of Medicine (, NCT00702026).

October 2013 -  Eur J Pain

Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: a role in pain symptom generation?


We hypothesized that increased pain perception in IBS could be explained by increased transcription in TRPV1 and/or altered levels of neuropeptides. We therefore assessed the transcription of TRPV1 and the mucosal concentration of somatostatin and SP in IBS in comparison to healthy volunteers and patients with ulcerative colitis (UC) in remission as disease controls, and to ascertain their relationship to pain symptoms.


Increased transcription of TRPV1 may provide a possible explanation for pain generation in IBS. While the neuropeptides SP and somatostatin were both found to be increased in IBS, these changes are not sufficient to explain pain generation. Pain generation in IBS is probably explained by a complex redundancy in the regulation of local nociceptive mechanisms, which remains a subject of intensive investigation.

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January 2013 - Colorectal Dis

Effect of cholecystokinin on rectal motor and sensory function in patients with irritable bowel syndrome and healthy controls


Ingestion of a meal frequently induces an urge to defaecate, the so-called gastro-colonic or gastro-rectal reflex. In patients with irritable bowel syndrome (IBS), symptoms are often provoked by meals. Cholecystokinin (CCK), a proximal gut peptide released after ingestion of a meal, may mediate these postprandial changes. The potential role of CCK in rectal sensory and motor function was evaluated by a rectal barostat study in healthy controls and patients with IBS.


Infusion of exogenous CCK to plasma levels normally seen in the postprandial state did not influence rectal motor function or sensations during ramp distension but it did significantly increase pain sensation in IBS patients during rapid intermittent distension.

November 2012 - Eur J Pain

Revisiting concepts of visceral nociception in irritable bowel syndrome


Irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain related to defecation with a change in bowel habit. Patients with IBS often exhibit increased visceral sensitivity, which can be tested clinically by rectal balloon distension procedures. This paper aims to give an overview of mechanisms involved in visceral hypersensitivity in IBS by reviewing recent literature.


Alterations in the modulatory balance of pro- and antinociceptive central processing of noxious peripheral input may serve as in integrative hypothesis for explaining visceral hypersensitivity in IBS. Nevertheless, it remains troublesome to estimate the contribution of central and peripheral factors in visceral hypersensitivity, posing a challenge in determining effective therapeutic entities.

August 2012 - Neurogastorenterol Motil

Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff


We aimed to calculate the optimal cutoff to detect visceral hypersensitivity in IBS.


Optimal cutoff for visceral hypersensitivity was found at pressure 26 mmHg with a VAS ≥20 mm, resulting in 63.5% of IBS patients being hypersensitive and 11% being allodynic. Standardization of barostat procedures and defining optimal cutoff values for hypersensitivity is warranted when employing rectal barostat measurements for research or clinical purposes.

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January 2012 - Neurogastroenterol Motil

Does meal ingestion enhance sensitivity of visceroperception assessment in irritable bowel syndrome?


We investigated whether meal ingestion could increase the sensitivity of the barostat procedure for the detection of visceral hypersensitivity in IBS patients.


Postprandial barostat measurement enhances visceroperception in IBS but has no added value to detect visceral hypersensitivity in individual IBS patients.